Journal article
High-resolution pulmonary ventilation and perfusion PET/CT allows for functionally adapted intensity modulated radiotherapy in lung cancer
S Siva, R Thomas, J Callahan, N Hardcastle, D Pham, T Kron, RJ Hicks, MP MacManus, DL Ball, MS Hofman
Radiotherapy and Oncology | Published : 2015
Abstract
Background and purpose: To assess the utility of functional lung avoidance using IMRT informed by four-dimensional (4D) ventilation/perfusion (V/Q) PET/CT. Materials and methods: In a prospective clinical trial, patients with non-small cell lung cancer (NSCLC) underwent 4D-V/Q PET/CT scanning before 60 Gy of definitive chemoradiation. Both "highly perfused" (HPLung) and "highly ventilated" (HVLung) lung volumes were delineated using a 70th centile SUV threshold, and a "ventilated lung volume" (VLung) was created using a 50th centile SUV threshold. For each patient four IMRT plans were created, optimised to the anatomical lung, HPLung, HVLung and VLung volumes, respectively. Improvements in f..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
Dr. Shankar Siva has received National Health and Medical Research Council scholarship funding for this research, APP1038399. This research is supported by funding from the Cancer Australia Priority-driven Collaborative Cancer Research Scheme (Project No. 1060919).